Cannabinoid CBG

What are the Cannabigerol (CBG) Cannabinoid Effects?

The non-pyschoactive cannabinoid cannabigerol (CBG) is one of the lesser known cannabinoids in cannabis. Although you may not be familiar with it, its impact on the biochemistry of the cannabis plant is monumental. It is known as the “mother cannabinoid.” This article explains what that means, highlights its benefits and conditions that it may treat, and lists strains high in CBG.

Cannabigerol (CBG) Cannabinoid Effects

CBGA is the precursor to the three major cannabinoids in cannabis, THCA, CBDA and CBCA. Natural enzymes in the cannabis plant, known as synthases, break down CBGA so that it forms into the three cannabinoids by way of the THC-synthase, CBD-synthase and the CBC-synthase.

Most cannabis strains contain amounts of CBG between 0.1 and 1%. Cannabis researchers have discovered that industrial hemp contains a much higher content of CBG; as much as 94%. The reason for this may be that a recessive gene of the cannabis plant stops it from producing one of the aforementioned synthases. That allows it to remain in its CBG form rather than converting into one of the other cannabinoids. Cultivators have figured out that they can extract higher amounts of CBG during the best extraction time, about 6 weeks into the 8 week flower cycle.

Like most of the lesser cannabinoids, there is very little research on CBG and its effects. It appears to be much more effective when it is used in conjunction with other cannabinoids, THC and CBD, known as “The Entourage Effect.”

CBG is considered to be an antagonist of the CB1-receptor that affects the central nervous system. As a result, it appears to counteract some of the paranoid high of THC. Researchers have also discovered that it affects the CB2-receptor, which affects the body. It is unknown if CBG inhibits or promotes such activity.

CBG may also increase anandamide levels, a naturally occurring cannabinoid produced by the endocannabinoid system (ECS). Anandamide, also known as “the bliss molecule,” not only heightens your state of happiness, but it plays a role in pain, appetite, fertility and inhibits cancer cell production.

Benefits of Cannabigerol  

  • Anti-inflammatory, especially in its acid form, CBGA.
  • Antibacterial
  • Anticancer and antitumor
  • Antidepressant and anxiolytic
  • Analgesic
  • Promotes bone growth
  • Appetite stimulant
  • Neuroprotective
  • Vasodilator
  • Sedative
  • Muscle relaxant

Conditions That Cannabigerol May Treat

  • Irritable Bowel Syndrome
  • Cachexia, anorexia and weight loss from chemotherapy treatments
  • Glaucoma
  • Psoriasis and other skin disorders
  • Anxiety and depression
  • Muscle tension and muscle spasms
  • MRSA
  • Neurological diseases such as Huntington’s Disease
  • Chronic pain
  • Insomnia

Research Studies Using CBG

Several research studies have given encouraging results suggesting that CBG may be particularly effective in treating glaucoma. It aids in the reduction of intraocular pressure by facilitating better drainage of fluid from the eye.

An animal study using mice found that CBG may be effective in decreasing inflammation in the bowel by inhibiting bladder contractions, which left unchecked may lead to bladder dysfunction.

A 2015 study at the Universidad Complutense, Madrid, Spain, using mice with Huntington’s disease, showed promise in the use of CBG to protect brain neurons by decreasing their cell degeneration.

A series of studies in Naples, Italy, published in 2014, suggested that CBG may be effective in blocking receptors that cause the growth of cancer cells. In one study, CBG inhibited the growth of colorectal cancer cells, opening up the possibility of treatment for colorectal cancer.

A 2008 study at the Dipartimento do Scienze Chimiche in Novara, Italy, demonstrated that CBG may be a strong antibacterial agent capable of treating MRSA which is resistant to many types of antibiotics.

A 2017 rat study, using a form of CBG from which delta-9 THC was removed, appears to be effective as an appetite stimulant. For those with cachexia, anorexia, severe hyperemesis and nausea/vomiting as a result of chemotherapy treatments, CBG looks to be a possible therapeutic option.

Cannabis Strains With High CBG Content

William’s Wonder  0.801 or 30% CBG
Allen Wrench     0.772
Exodus Cheese    0.400 or 15% CBG
Animal Cookies    0.319
Destroyer and Magic Jordan are also high in CBG content

Sources:, What is CBG and What Are the Benefits of This Cannabinoid? Jacqueline Havelka, Cannabigerol (CBG): A Minor Cannabinoid With A Major Impact, Drake Dorm, Cannabigerol (CBG): What is Cannabigerol? Jan 30, 21019