CBD Cannabinoid

What are the Cannabidiol (CBD) Cannabinoid effects?

Cannabidiol (CBD) is the second most prevalent cannabinoid in the cannabis plant after THC. It is non-intoxicating and not only boosts the medicinal effects of THC, but is now known to help counteract the psychotropic effects of THC. This article examines its benefits, the conditions it may effectively treat and lists some of the most common high-CBD cannabis strains.

CBD, along with CBC, CBG, CBN and THC, work together, synergistically, to provide a myriad of medicinal benefits as part of the “Entourage Effect.”

CBD is produced by both cannabis and hemp plants. CBD products which contain less than 0.3% THC are legal to sell on store shelves and online and may be transported across the US. CBD products which contain more than 0.3% THC may only be purchased in states where medical and recreational cannabis are legal. The cannabis plant produces high-CBD resin in greater amounts than does the hemp plant.

There are many different forms of CBD products which vary based on the type of CBD, the extraction and the manufacturing processes used.

There are oils, isolates, waxes, crystals, liquids, capsules and full spectrum extracts.

Extraction Methods

  • Oil Extraction with Liquid Solvent
  • CO2 Extraction
  • Extraction in a Tincture
  • Oil Extraction
  • Extraction by Molecular Separation

CBD does not directly interact with the two main cannabinoid receptors, CB1 and CB2. CBD counteracts the psychotropic side effects of THC such as anxiety and memory impairment by blocking its activation of the CB1 receptor, the major endocannabinoid receptor (ECS) in the brain. That is why if you ingest too much THC, the antidote is to ingest CBD.

CBD has so many potential therapeutic benefits due to its ability to impact a wide array of receptors, not limited to cannabinoids, in the brain and body. These include:

  • Opioid receptors which regulate pain
  • Dopamine receptors which play a key role in managing behaviors such as motivation and reward-seeking
  • Serotonin receptors which regulate mood
  • Adenosine receptors which regulate sleep and wake cycles
  • Vanilloid receptors which control pain signals

CBD also blocks FAAH, a fatty acid that breaks down anandamide, a natural endocannabinoid, known as the “bliss molecule.” It regulates the immune system and body temperature and reduces inflammation. The more anandamide you have available, the more regulated are all your body systems. CBD facilitates the increase of anandamide by blocking FAAH from breaking down anandamide into small parts.

Benefits of CBD

  • Anti-inflammatory
  • Analgesic
  • Anxiolytic
  • Antiemetic
  • Antipsychotic
  • Antibacterial
  • Antioxidant
  • Sedative
  • Anticancer
  • Anticonvulsant
  • Antidepressant
  • Neuroprotective
  • Immune system booster
  • Improves bone growth
  • Antispasmodic
  • Reduces diabetic risk
  • Improves skin health
  • Treats addiction

Conditions That CBD May Treat

  • Seizures and Epilepsy, especially in children with Dravet syndrome and Lennox-Gastaut syndrome
  • Chronic pain
  • Neuropathy
  • Colitis and Crohn’s Disease
  • ADD & ADHD
  • Cancer
  • Autoimmune Diseases such as Lupus, Fibromyalgia and Rheumatoid Arthritis
  • PTSD, Anxiety, OCD, Psychosis and Bipolar disorder
  • Opioid Withdrawal Symptoms
  • Nausea and Vomiting
  • Insomnia
  • Diabetes
  • Dystonia
  • Kidney Disease
  • Liver Disease
  • Osteoporosis
  • Neurological and Motor Disorders such as ALS, MS, Parkinson’s Disease and Alzheimer’s Disease
  • Irritable Bowl Syndrome and Inflammatory Bowel Disorder
  • Anorexia
  • Antibiotic Resistance
  • Osteoarthritis
  • Asthma
  • Autism Spectrum Disorders
  • Glaucoma
  • Migraines
  • Skin Conditions
  • Stroke
  • Traumatic Brain Injury
  • Obesity

One of the first disorders that CBD was able to control successfully was Dravet’s Syndrome, an intractable seizure disorder seen in very young children. Sufferers experienced hundreds of seizures on a daily basis which impeded their development and stunted their growth. The Colorado based Stanley Brothers famously developed Charlotte’s Web, named after Charlotte Figi. Her desperate parents approached the family for help in saving their daughter’s life. She not only survived, but she thrived. Hundreds of thousands of children and adults are seizure free thanks to the Figis and the Stanleys.

There have been numerous human studies where CBD was shown to reduce the number of seizures and even stop them altogether. The FDA recently approved Epidiolex, the first cannabis-derived treatment for seizure disorders and epilepsy.

High-CBD Strains

AC/DC                  8.93
Valentine X              8.86
Super Lemon Haze     8.78
Harlequin              8.67
Pure OG               7.88
Cannatonic             7.63

Charlotte’s Web, Ringo’s Gift, Harle-Tsu, Canna-Tsu are also high-CBD strains

As of this writing, this are still no FDA regulations overseeing the production of CBD products, so if you are considering purchasing CBD, it is best to purchase it through your dispensary or a reputable source.

There is too much information about the CBD market to include in this post, so if you are new to CBD products, please do some research, check out some of my sources below and also ask others with experience to guide you.

leafly.com, CBD (Cannabidiol): What Does It Do & How Does It Affect the Brain & Body
marijuanadoctors.com, Cannabidiol (CBD), January 17, 2019
projectcbd.org, Conditions
health.harvard.edu, Cannabidiol (CBD)—What We Know and What We Don’t, Peter Grinspoon, MD, updated June 5, 2019
naturalstacks.com, The Many Forms of CBD: Oils, Isolate, Wax , Crystals and Capsules Explained, Roy Krebs, June 20, 2019