What are the Cannabichromene (CBC) Cannabinoid Effects?

Today’s article features one of the major phytocannabinoids of the cannabis plant, Cannabichromene (CBC). I will be discussing its benefits, the conditions it may treat and how it works. I will include a list of some of the strains that contain appreciable amounts of CBC.

CBC - Cannabichromene Cannabinoid

Although CBC is not as widely known as the more famous cannabinoids, THC and CBD, it is the third most prevalent cannabinoid. It is thought to be non-psychotropic. It is thought to be much more effective when it works in conjunction with THC and CBD, known as the Entourage Effect.

Discovered in 1966, CBC is chemically similar to the other important cannabinoids, THC, CBD, CBN and THCV. Research suggests that its strongest effects are in pain relief, reduction of inflammation and in neurogenesis. The amount of CBC found in today’s strains is much smaller than in those of the other major cannabinoids.

Benefits of CBC

  • Anti-inflammatory
  • Analgesic
  • Anti-bacterial, anti-fungal and anti-microbial
  • Antidepressant
  • Stimulates neurogenesis
  • Antiproliferative
  • Anti-viral
  • Assists with digestive and gastrointestinal disorders

Conditions That CBC May Treat

  • Irritable Bowel Syndrome
  • Crohn’s Disease
  • Neuropathy
  • Chronic Post-Operative Pain
  • Arthritis
  • Migraines
  • Acne
  • Stress and Depression
  • Neurodegenerative Disorders

How Does CBC Work?

CBC binds minimally with CB1 and CB2 receptors, yet it reduces inflammation. It does this by activating specific phytocannabinoid receptors on cell members which may lead to controlling cell inflammation.

It does bind with the other pain receptors, TRPA1 and TRPV1, which are the first sensors that alert the brain to pain and swelling. TRP stands for “transient receptor potential channels” which send out alarm signals to the brain and body that pain and inflammation are present.

CBC stimulates 2-AG and anandamide, 2 of the body’s natural endocannabinoids. In the case of anandamide, CBC inhibits its uptake which allows it to stay longer in the bloodstream, prolonging its calming effects.

Very little research has been done on CBC, mostly using rats and mice, with few human trials. However, the data from those studies has shown the following positive results:

A 2013 study using mice showed evidence that CBC may encourage the growth of new neuron growth in the brain. This has exciting implications in treating cell degeneration conditions such as Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and MS.

Stress and Depression Relief
A study using rats at the University of Mississippi found that CBC usage may increase performance on stress tests.

Pain Relief
A 2011 Italian study found that CBC, in conjunction with CBD, may produce pain relief in rats.

Studies going back to the 1980s indicate that CBC may be effective in killing life-threatening bacteria such as E. coli.

A 2010 study found that CBC alone may reduce inflammation. However, it is much more effective when combined with THC and CBD.

Acne Treatment
New research published in 2016 in the Journal for Experimental Dermatology indicated that CBC may decrease the production of sebum by the sebaceous glands. This decreases the impact of arachidonic acid, an inflammatory fatty acid, on the skin and glands.

Strains Containing CBC

Research going back to the 1970s suggests that indigenous or landrace strains from India contain the highest levels of CBC. Some of these strains may have even higher levels of CBC than CBD. CBC is more prevalent in young plants. When exposed to heat and light, it degrades to cannabicyclol.

  • Birthday Cake    0.726
  • Purple Cadillac   0.719
  • Platinum Cookies  0.533
  • Maui Dream      0.487
  • Bubba Cookies    0.462
  • Blue Cherry Soda  0.462
  • 3 Kings          0.461

Here is a list of strains at Bloom Medicinals with high CBC content:

analyticalcannabis.com, CBC: A Look at the Potential Therapeutic Value of this Major Cannabinoid, Oct 30, 2018, Leo Bear-McGuinness
originalfarm. com, What Is CBC?
weedmaps.com, Beyond THC and CBD: Why Lesser Known Cannabinoids Are Important, Too, May 22, 2019, Tyler Koslow
Potbiotics.com, Strains